*This article is a popular science article for the public to learn about common weight loss drugs on the market, and is not intended for the purpose of selling drugs. Our hospital advocates scientific weight loss, and some of the weight loss drugs mentioned in the article are prescription drugs that need to be used after being evaluated by a doctor for suitability in a regular medical institution.

 

On June 27, 2025, the glucagon (GCG)/glucagon like peptide-1 (GLP-1) dual receptor agonist, mescalin, was officially announced to be launched in China.

 

July 2025, GLP-1R/GIPR The dual agonist Tilpotide Injection has been approved for a new indication and can be used to treat moderate to severe obstructive sleep apnea (OSA) in adult obese patients, becoming the first and currently the only prescription drug for this indication.

 

The selection of weight loss drugs has become more diverse. What are the characteristics of this new drug, and what are the similarities and differences among various related preparations?This article will take you through the relevant content.

 

 

Family photo of weight loss medication already on the market in China

From the table above, it can be seen that research on weight loss drugs is constantly updating and iterating in terms of their mechanisms of action and targets, starting from a single GLP-1 From the main effect to the subsequent dual targets, such as GLP-1 Acceptor and GIPR、GCG The joint effect.

 

From daily administration and injection, it has developed into weekly medication.

 

Different drugs have their own advantages and disadvantages, and the emergence of new treatment options is undoubtedly a blessing for patients. With the growth of the "family" of weight loss drugs, treatment strategies for different complications related to weight can also be more refined, allowing doctors to choose drugs with different targets based on the specific personal situation of patients.

 

As a new drug, Masidomide has attracted a lot of attention recently. Therefore, this article also provides some supplementary science popularization on the drug. If you want to learn more about the detailed science popularization of semaglutide and tilpotide, you can also check out our historical science popularization articles.

 

The Drug Mechanism of Masidopeptide

 

Masidu Peptide is the world's first GCG/GLP-1 Dual receptor agonists for weight loss, through activation GLP-1 The host will suppress the user's appetite, and on this basis, it will also activate simultaneously GCG Acceptor, promotes fat burning and reduces visceral fat content. The simultaneous action of dual targets reflects the weight loss effect of Masidomide peptide.

 

Suitable population for Masidomide

The approved indications for Masidu peptide are:

On the basis of controlling diet and increasing physical activity, the initial body mass index (BMI) for long-term weight control in adult patients is:

•BMI≥28 kg/m2（ Obesity), or

•BMI≥24 kg/m2（ Overweight, accompanied by at least one weight related complication (such as hyperglycemia, hypertension, dyslipidemia, fatty liver, obstructive sleep apnea syndrome, etc.).

 

*Please have the doctor evaluate the specific situation

 

Fatty liver, as a major complication of body weight, is also a problem that many "society people" are currently struggling with. One of the functions of Masidogrel is to GCG The receptor is mainly expressed in the liver by activating the liver GCG The receptor will directly affect liver glucose and lipid metabolism, inflammation, and fibrosis processes.

 

 

In most cases, there is no right or wrong medication treatment, but there are advantages and disadvantages. I also encourage everyone to communicate with doctors in both directions during physical examinations or seeking medical treatment, and jointly negotiate the most suitable treatment plan for you!

 

But in the end, I still said the same old thing,Medications are used to treat diseases. To ensure medication safety, all medications must undergo a comprehensive evaluation by a doctor before use, be used correctly under the guidance of a doctor or pharmacist, and cultivate good eating and exercise habits. Do not use any medication without any guidance!

 

Outpatient appointment information

Our hospital's comprehensive department can provide weight management services for customers. The weight management team includes general practitioners, clinical nutritionists, and clinical pharmacists, who can provide personalized dietary and exercise advice for overweight or obese individuals, as well as conduct medication evaluations.

 

Note: As a medical institution, our hospital strictly adheres to clinical diagnosis and treatment standards in drug sales and does not directly sell drugs to patients.